What question did this study set out to answer?

This research aims to understand how large arteries and peripheral load affect pressure wave propagation in the human upper limb.

October 1, 1995AJP Heart and Circulatory Physiology

Pressure wave propagation in a multibranched model of the human upper limb

Q: What does this research mean for the field?

In the human upper limb, the properties of the peripheral vascular load exert a substantially greater influence on pressure wave propagation than the viscoelastic properties of the large arteries. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Population

Anatomically realistic multibranched model of the human upper limb based on linear transmission theory

Design

Preclinical

Authors

MKMustafa KaramanogluMedtronic (Ireland)DGDavid GallagherCalvary Riverina Hospital AAAlberto AvolioVascular Medicine

Discussion

Member takes

Implication

Peripheral load may predominate in wave propagation models; extends computational hemodynamics but leaves open clinical translation pending validation.

Key Points

This research aims to understand how large arteries and peripheral load affect pressure wave propagation in the human upper limb.
Developed an anatomically realistic multibranched model based on linear transmission theory.
Altered viscoelastic properties of arteries and peripheral loads, adjusting Young's modulus and windkessel parameters.
Analyzed the relationship between central aortic and peripheral radial pressure waveforms in both time and frequency domains.
Large arterial properties influenced peak systolic pressure by 3% and transfer function peak by 29%.
Peripheral load properties affected systolic pressure by 14% and transfer function peak by 74%.

Structured PICO

Population

Anatomically realistic multibranched model of the human upper limb based on linear transmission theory

Intervention

Alteration of viscoelastic properties of large arteries and peripheral load properties (Young's modulus, phase of complex elastance, windkessel time constant, and peripheral reflection coefficient)

Outcome

Relationship between the central aortic and peripheral radial pressure waveforms in the time and the frequency domainsurrogate

In a computational model of the human upper limb, peripheral load properties exert a substantially greater influence on pressure wave propagation than the viscoelastic properties of large arteries.

Cite This Study

Karamanoglu et al. (1995) studied this question.

synapsesocial.com/papers/6a17a0464f2b3115b012ce06 https://doi.org/10.1152/ajpheart.1995.269.4.h1363

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Implication

Peripheral load may predominate in wave propagation models; extends computational hemodynamics but leaves open clinical translation pending validation.

Pressure wave propagation in a multibranched model of the human upper limb

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Pressure wave propagation in a multibranched model of the human upper limb

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider