Key result
Full-body 3D arterial multi-scale modeling successfully reproduces physiological pressure and flow waveforms.
Why the study?
Changes in arterial wall properties affect hemodynamic indices and progress spatially and temporally in conditions like aging and hypertension, requiring detailed modeling to understand their impact on global hemodynamics.
Population
Three-dimensional deformable full-body arterial network models
Design
Multi-scale simulation study of unsteady blood flow and pressure
Authors
Loading...
May advance in silico studies of arterial stiffening and hypertension; leaves open clinical translation pending validation.
This novel 3D multi-scale simulation framework successfully models full-body arterial hemodynamics, providing a computational tool to study age-related arterial stiffening and hypertension.
Figueroa et al. (2014) studied Aging and hypertension. Multi-scale simulation framework was evaluated on Pressure and flow waveforms, regional blood flow distribution, pressure pulse amplification and pulse wave velocity. A multi-scale simulation framework of a 3D deformable full-body arterial network successfully demonstrated realistic pressure and flow waveforms, regional blood flow, and pulse wave velocity.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: