Key result
Large animal models serve as valuable tools for investigating new pharmacological interventions for AF.
Why the study?
Animal models reflecting human phenotypes are needed to understand the mechanisms of AF and test new pharmacological interventions.
Large animal models, such as pigs, goats, dogs, and horses, are valuable preclinical tools for investigating the mechanisms of atrial fibrillation and testing new anti-arrhythmic pharmacological interventions.
Encourages large animal models for AF drug discovery; leaves open translation to human therapies.
Atrial fibrillation (AF) constitutes an increasing health problem in the aging population. Animal models reflecting human phenotypes are needed to understand the mechanisms of AF, as well as to test new pharmacological interventions. In recent years, a number of large animal models, primarily pigs, goats, dog and horses have been used in AF research. These animals can to a certain extent recapitulate the human pathophysiological characteristics and serve as valuable tools in investigating new pharmacological interventions for treating AF. This review focuses on anti‐arrhythmic investigations in large animals. Initially, spontaneous AF in small and large mammals is discussed. This is followed by a short presentation of frequently used methods for inducing short‐ and long‐term AF. The major focus of the review is on anti‐arrhythmic compounds either frequently used in the human clinic (ranolazine, flecainide, vernakalant and amiodarone) or being promising new AF medicine candidates ( I K,Ach , I SK,Ca and I K2P blockers). LINKED ARTICLES This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc
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Saljic et al. (2021) conducted a review in Atrial fibrillation. Anti-arrhythmic compounds was evaluated. Large animal models, primarily pigs, goats, dogs, and horses, serve as valuable tools for investigating new pharmacological interventions for treating atrial fibrillation.
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