Key result
Robotic partial nephrectomy and R-CHOP yield 1.5-year remission in synchronous intravascular lymphoma and RCC.
Why the study?
Intravascular large B-cell lymphoma is rare and aggressive, with renal involvement rarely reported and synchronous occurrence with renal cell carcinoma being extremely rare.
Case Report (n=1)
No
This is the first reported case of synchronous intravascular large B-cell lymphoma with renal cell carcinoma detected by robot-assisted partial nephrectomy, successfully treated with R-CHOP.
May support combined partial nephrectomy and R-CHOP for this rare synchronous malignancy; hypothesis-generating case report leaves optimal management open.
Introduction: Intravascular large B-cell lymphoma is a rare and aggressive type of extranodal large B-cell lymphoma. Although intravascular large B-cell lymphoma can invade various organs, renal involvement has been rarely reported. Synchronous occurrence of intravascular lymphoma with renal cell carcinoma is extremely rare. We herein report a case of intravascular large B-cell lymphoma in a renal cell carcinoma incidentally detected by robot-assisted partial nephrectomy. Case presentation: A 69-year-old female with recurrent fever lasting 4 years underwent robot-assisted partial nephrectomy for small renal cell carcinoma. Histological findings led to the diagnosis of intravascular large B-cell lymphoma, which involved the normal tissue of right kidney as well as clear cell renal cell carcinoma. She received six cycles of chemotherapy without major complications and achieved complete remission. Conclusion: We encountered a rare case of synchronous intravascular lymphoma with renal cell carcinoma.
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Noda et al. (2022) conducted a case report in Intravascular large B-cell lymphoma in renal cell carcinoma (n=1). Robot-assisted partial nephrectomy and R-CHOP chemotherapy was evaluated on Complete remission and recurrence-free survival. A 69-year-old female with synchronous intravascular large B-cell lymphoma and renal cell carcinoma achieved complete remission without recurrence for 1.5 years following robot-assisted partial nephrectomy and R-CHOP chemotherapy.
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