Key result
Angiotensin II-induced increases in mean arterial pressure (151 vs 123 mm Hg), salt intake, and cardiac hypertrophy were significantly attenuated in TNF-alpha knockout mice compared to wild-type.
Why the study?
Does TNF-alpha knockout prevent Angiotensin II-induced salt appetite, hypertension, and cardiac hypertrophy in mice?
Does TNF-alpha knockout prevent Angiotensin II-induced salt appetite, hypertension, and cardiac hypertrophy in mice?
TNF-alpha plays a mechanistic role in mediating chronic Angiotensin II-induced effects on salt appetite, blood pressure, and cardiac hypertrophy in mice.
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TNF-alpha inhibition merits study in hypertension models; animal findings leave open human translation.
Sriramula et al. (2008) studied Hypertension. Angiotensin II vs. Wild-type mice was evaluated on Salt intake, water intake, and mean arterial pressure. Angiotensin II-induced increases in mean arterial pressure (151 vs 123 mm Hg), salt intake, and cardiac hypertrophy were significantly attenuated in TNF-alpha knockout mice compared to wild-type.
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