Key result
Concomitant HF is linked to ~80% higher total mortality in patients with sepsis.
Why the study?
Heart failure often affects the course of sepsis, but its impact on outcomes remains inconsistent and inconclusive.
Does heart failure increase mortality in patients with sepsis?
Meta-Analysis (n=35,712)
Does heart failure increase mortality in patients with sepsis?
Heart failure, particularly right ventricular dysfunction, significantly increases the risk of death in patients with sepsis, highlighting the need for highly monitored treatment in this population.
May warrant closer monitoring in sepsis with heart failure; leaves open whether association is causal or modifiable.
BACKGROUND: Heart failure (HF) often affects the progress of sepsis patients, although its impact on outcomes is inconsistent and inconclusive. AIM: To conduct a systematic review and meta-analysis of the impact of HF on mortality in patients with sepsis. METHODS: PubMed, Embase, Web of Science, and the Cochrane Library databases were searched to compare the outcomes of sepsis patients with HF. A random effect model was used to summarize the mortality data, and the odds ratio (OR) and 95% confidence interval (CI) were calculated as effect indicators. RESULTS: = 91.5%) increased significantly. CONCLUSION: In patients with sepsis, HF is often associated with adverse outcomes and mortality. Our results call for more high-quality research and strategies to improve outcomes for sepsis patients with HF.
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Zhu et al. (2023) conducted a meta-analysis in Sepsis (n=35,712). Heart failure vs. Sepsis without heart failure was evaluated on Total mortality (OR 1.80, 95% CI 1.34-2.43, p=<0.001). In patients with sepsis, concomitant heart failure was significantly associated with increased total mortality (OR 1.80).
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