Key result
The moderator band provides a substrate for macroreentrant ventricular tachycardia, driven by action potential duration gradients between the right ventricular free wall and moderator band (P<0.0001).
The moderator band exhibits anatomic and electrical compartmentalization between myocardium and Purkinje fibers, providing a unique substrate for macroreentrant ventricular tachycardia.
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Animal findings do not alter human VT management; leaves open moderator band as ablation target pending clinical studies.
Walton et al. (2018) studied Ventricular Tachycardia (n=17). S1S2 pacing of the right ventricular free wall, moderator band, or combined sites was evaluated on Incidence of ventricular tachycardia and action potential duration. The moderator band provides a substrate for macroreentrant ventricular tachycardia, driven by action potential duration gradients between the right ventricular free wall and moderator band (P<0.0001).
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