Key result
Integrating CAD polygenic risk scores into workplace programs improves QALYs and saves ~$53 per employee.
Why the study?
Workplaces provide a conductive environment for cardiovascular prevention, but the cost-effectiveness of integrating CAD-PRS into workplace prevention programs remains unknown.
Does integrating CAD-PRS in a workplace cardiovascular disease prevention program improve cost-effectiveness and QALYs compared to standard or no workplace programs in employees?
Population
Simulated cohort of employees with a mean age of 50 years
Comparison
CardioriskSCORE vs Standard-WHP vs No-WHP
Design
Cohort simulation model cost-effectiveness analysis
Follow-up
5 years
Authors
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Dominant in modeling; leaves open confirmation of real-world QALY gains and cost savings in randomized workplace trials.
Does integrating CAD-PRS in a workplace cardiovascular disease prevention program improve cost-effectiveness and QALYs compared to standard or no workplace programs in employees?
Effect estimate: Dominant
Implementing a polygenic risk score for coronary artery disease in a workplace prevention program is projected to be a cost-saving and effective strategy for improving employee health and reducing employer costs.
Mujwara et al. (2023) studied Cardiovascular disease prevention (n=47,108). CardioriskSCORE (CAD-PRS integrated with pooled cohort equation) vs. Standard workplace healthcare program (Standard-WHP) and No-workplace health program (No-WHP) was evaluated on Incremental cost-effectiveness ratio (ICER) (Dominant). Integrating a polygenic risk score for coronary artery disease in a workplace prevention program was a dominant strategy, lowering costs by $53 and improving quality-adjusted life years by 0.001 per employee compared to a standard workplace program.
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