Key result
The apolipoprotein B gene rs693 T allele was associated with a significantly elevated risk of calcific aortic stenosis compared to the CC genotype (AOR 1.58).
Why the study?
Do apolipoprotein B genetic polymorphisms increase the risk of calcific aortic stenosis in Chinese subjects?
Case-Control (n=966)
No
Do apolipoprotein B genetic polymorphisms increase the risk of calcific aortic stenosis in Chinese subjects?
Effect estimate: AOR 1.58 (95% CI 1.182-2.103)
p-value: p=0.002
Apolipoprotein B genetic polymorphisms (rs693 and rs6725189) are independently associated with an increased risk of calcific aortic stenosis in the Han Chinese population.
Should not yet change CAS risk stratification; leaves open whether rs693 genotyping aids prediction in Han Chinese.
BACKGROUND: Limited information is available when it comes to the impact of genetic on Calcific Aortic Stenosis (CAS). Apolipoprotein B (apoB) is a key component in lipid metabolism and plays an important role in the dynamic equilibrium of cholesterol. We performed a case-control study to explore the association of apoB genetic polymorphisms with CAS in Chinese subjects, in Xinjiang, China. METHODS: We designed a case-control study including 314 CAS patients and 652 age- and sex-matched control subjects. Using the polymerase chain reaction-restriction fragment length (PCR-RFLP) method, we genotyped two SNPs (rs6725189 and rs693) of apoB gene in all subjects. RESULTS: We found that the rs693 T allele was associated with a significantly elevated CAS risk [TT/CT vs. CC: adjusted odds ratio (AOR) = 1.58, 95% confidence interval (CI) = 1.82-2.10, P = 0.002] and the rs6725189 T allele was also associated with a significantly elevated CAS risk (GT vs. GG: AOR = 1.82, 95% CI = 1.14-2.92, P = 0.013). Furthermore, we also found that the TC levels were significantly higher in rs693 TT/CT genotypes than that in CC genotypes (P < 0.05). CONCLUSIONS: Both rs693 and rs6725189 of the apoB gene are associated with CAS in Chinese subjects, in Xinjiang, China.
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Wang et al. (2018) conducted a case-control in Calcific Aortic Stenosis (CAS) (n=966). Apolipoprotein B (apoB) genetic polymorphisms (rs693 and rs6725189) vs. Wild-type/Control genotypes (rs693 CC, rs6725189 GG) was evaluated on Risk of calcific aortic stenosis (CAS) for rs693 TT/CT vs CC (AOR 1.58, 95% CI 1.182-2.103, p=0.002). The apolipoprotein B gene rs693 T allele was associated with a significantly elevated risk of calcific aortic stenosis compared to the CC genotype (AOR 1.58).
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