Key result
Apolipoprotein E4 allele frequency was not significantly different between calcific aortic stenosis cases and controls (32% vs 28%, p=0.622), though it was associated with higher lipid levels.
Why the study?
This study aimed to investigate the impact of Apo E polymorphisms on plasma lipid profiles and identify Apo E gene polymorphisms as genetic predictors of calcific aortic stenosis in a Pakistani population.
Does Apo E gene polymorphism predict the presence of calcific aortic stenosis or dyslipidemia in elderly patients?
Case-Control (n=100)
Yes
Does Apo E gene polymorphism predict the presence of calcific aortic stenosis or dyslipidemia in elderly patients?
Absolute Event Rate: 32% vs 28%
p-value: p=0.622
The Apo E4 allele is associated with an increased risk of dyslipidemia but does not appear to be a genetic predictor for calcific aortic stenosis in this Pakistani cohort.
Objective: This study aimed to investigate the impact of the Apo E polymorphisms on plasma lipid profile and to identify the polymorphism of the apo-E gene as genetic predictor of calcific AS in Pakistani population. Methodology: This was a case control study conducted in Dow University of Health Sciences and National Institute of Cardiovascular Disease, Karachi. It included total of 100 individuals, 50 echocardiographically identified calcific AS cases and 50 age and gender matched controls. Apo E allele frequencies were computed, lipid profiles were estimated and Apo E gene polymorphism was identified by the techniques of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Result: Apo E 2, 3, and 4 allele frequencies were 16%, 52%, and 32% in calcific AS cases, and 10%, 52%, 28% in controls respectively (p=0.622). Out of 50 cases, 18% presented with mild AS, 22% moderate AS and 60% lied in severe calcific AS. It was observed that levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) were higher in Apo E4 allele as compared to other genes in both cases and control. Conclusion: The findings of this study suggested that Apo E4 allele of Apo E gene is an impotent risk factors for dyslipidemia while Apo E4 allele is not associated with calcific AS contemplates distinctive genetic backgrounds of CAD and AS.
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Afaq et al. (2023) conducted a case-control in Calcific Aortic Stenosis (n=100). Apolipoprotein E (Apo E) polymorphism vs. Age- and gender-matched controls without calcific aortic stenosis was evaluated on Apo E4 allele frequency (p=0.622). Apolipoprotein E4 allele frequency was not significantly different between calcific aortic stenosis cases and controls (32% vs 28%, p=0.622), though it was associated with higher lipid levels.
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