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May 25, 2026Scientific ReportsOpen Access

Distinct molecular profile in Sjögren’s syndrome is associated with disease activity and clinical manifestations

Carlo Perricone Giacomo Cafaro Martina Nicchi Giulia Cruciani Biancamaria Pianese Lorenza Bruno Roberto Dal Pozzolo Roberta Cecchetti Matteo Antonucci Fabiana Topini Onelia Bistoni Patrizia Mecocci Roberto Gerli Elena Bartoloni

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Key Points

This research evaluates potential biomarkers in Sjögren's syndrome to improve diagnosis and disease stratification.
Analyzed sera from 40 Sjögren's syndrome patients and 41 matched controls using Luminex® multiplex immunoassay.
Examined correlations between clinical/laboratory data and inflammatory mediators.
Performed multivariate logistic regression to identify independent predictors.
Elevated IL-15 levels in SjD patients compared to controls (11.52 pg/ml vs. 1.37 pg/ml, P=0.0009).
TNFRII identified as a strong independent predictor of SjD (AUC = 0.89).
Correlation of IL-15 with hypergammaglobulinemia and MCP-1 with disease severity scores.

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Implication

Assesses biomarkers correlating with disease activity in Sjögren's syndrome, suggesting new diagnostic pathways.

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Cite This Study

Perricone et al. (2026) studied this question.

synapsesocial.com/papers/6a17daca3fad632b0f9d7bb1 https://doi.org/10.1038/s41598-026-54557-2

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