Iridium(III) Polypyridyl and Cyclometalated Complexes for DNA Targeting, Bioimaging, and Light-activated Therapeutics: Recent Progress, Mechanistic Insights, and Emerging Design Strategies—A Mini Review

Stephen Opeyemi Aderinto; Jim A. Thomas

doi:10.1039/d6dt00856a

January 1, 2026Dalton Transactions

Iridium(III) Polypyridyl and Cyclometalated Complexes for DNA Targeting, Bioimaging, and Light-activated Therapeutics: Recent Progress, Mechanistic Insights, and Emerging Design Strategies—A Mini Review

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Key Points

This review focuses on the recent progress and mechanistic insights of iridium(III) complexes in DNA targeting and light-activated therapies.
Surveyed and analyzed recent literature on iridium(III) polypyridyl and cyclometalated complexes.
Discussed applications including photocatalysis, optoelectronics, bioimaging, and photodynamic therapy.
Highlighted emerging design strategies for these complexes.
Iridium(III) complexes are increasingly recognized for their efficacy in DNA targeting and photodynamic therapy.
Mechanistic insights show enhanced biocompatibility and efficiency compared to traditional ruthenium(II) complexes.
Emerging design strategies indicate potential for greater functional diversity in therapeutic applications.

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Implication

Mini review highlights advances in iridium complexes for bioimaging and therapeutic applications, suggesting viable design strategies.

Abstract

Iridium(III) polypyridyl and cyclometalated complexes have emerged as highly versatile coordination compounds with applications spanning photocatalysis, optoelectronics, bioimaging, and photodynamic therapy. While ruthenium(II) polypyridyl complexes have historically dominated nucleic acid...

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Aderinto et al. (2026) studied this question.

synapsesocial.com/papers/6a17dbe93fad632b0f9d89c9 https://doi.org/10.1039/d6dt00856a

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Iridium(III) Polypyridyl and Cyclometalated Complexes for DNA Targeting, Bioimaging, and Light-activated Therapeutics: Recent Progress, Mechanistic Insights, and Emerging Design Strategies—A Mini Review

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Iridium(III) Polypyridyl and Cyclometalated Complexes for DNA Targeting, Bioimaging, and Light-activated Therapeutics: Recent Progress, Mechanistic Insights, and Emerging Design Strategies—A Mini Review

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