Review analysis investigates iridium(III) complexes' DNA-binding capabilities, highlighting their potential applications in therapeutics.
The increasingly diverse biological applications of iridium(III) complexes, from luminescent cellular imaging agents to therapeutic and prospective theranostics, has been enabled by a combination of imaginative ligand design and tunable (photo)physical properties. Within this biological context, it is crucial to understand how molecular probes interact with biological substrates and macromolecules. This review focuses upon the structural diversity of DNA‐binding metal complexes based upon iridium(III), the general workflow used to interrogate these interactions with DNA, and critically analyses the relationship between complex structure and functionality.
No takes yet. Share an insight, caveat, or question.
Alkhaibari et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: