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May 28, 2026Lab on a Chip0 citationsOpen Access

A dual-mode vertical flow assay for species-specific identification and total bacteria load assessment from a single urine sample

SSShu-Yun SheuNational Tsing Hua UniversityCSChing‐Fen ShenNational Cheng Kung University HospitalCCChao‐Min ChengNational Tsing Hua University

Key Points

  • The aim is to develop a dual-mode assay that can identify bacteria species and assess total bacteria load from a single urine sample.
  • Designed a vertical flow assay to analyze urine samples.
  • Tested for both pathogen identification and quantification of bacterial load.
  • Implemented species-specific detection methods.
  • Successful identification of targeted pathogens in 85% of urine samples.
  • Quantification of total bacteria load achieved with a sensitivity of 90%.
  • Showed significant correlation between assay results and conventional laboratory methods.

Abstract

Rapid urine screening would benefit from simultaneous determination of pathogen identity and clinically relevant bacteria burden, yet most paper-based assays provide only one of these outputs. Here, we report on...

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Cite This Study

Sheu et al. (2026) studied this question.

synapsesocial.com/papers/6a17dbe93fad632b0f9d8a12https://doi.org/10.1039/d6lc00265j
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