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Demonstrates hepatoprotection in hepatocytes and zebrafish embryos, indicating potential for liver disease treatment.
-induced oxidative damage in L02 cells, and it was further validated in zebrafish embryos, significantly restoring viability and reducing ROS and lipid peroxidation. By integrating bioactivity data with HPLC fingerprinting, we established a spectrum-effect relationship, which pinpointed four active constituents: cynaroside, apigenin-7-O-glucoside, oleuroside, and ligustroside. These compounds were found to bind to the Keap1 protein, potentially activating the Nrf2 antioxidant pathway. These results clarify the active components and mechanism of action of OLE, supporting its development as a natural antioxidant for liver diseases.
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Zhang et al. (2026) studied this question.
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