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Review highlights sustainable synthesis of quinazolinones using earth-abundant metal catalysts, suggesting greener alternatives.
The development of sustainable catalytic methods for the synthesis of biologically important quinazolinone derivatives has attracted significant attention in recent years. In this regard, earth‐abundant transition metals such as Fe, Cu, Co, Ni, Mn, and Zn have emerged as promising alternatives to conventional metal catalysts for the synthesis of quinazolinone frameworks. This review provides a focused overview of recent advances in earth‐abundant metal‐catalyzed approaches for the synthesis of quinazolinone derivatives. Particular emphasis has been placed on catalytic methodologies, substrate scope, reaction pathways, and mechanistic aspects. Overall, the article aims to present the progress achieved in this field and to highlight the potential of sustainable metal catalysis for the future development of efficient and greener quinazolinone synthesis.
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Kushwaha et al. (2026) studied this question.
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