Why the study?
Apart from NT-proBNP, the relationships between emerging biomarkers and ventricular systolic or diastolic dysfunction remain poorly investigated in patients eligible for cardiac surgery.
Do preoperative plasma levels of NT-proBNP, sST2, Galectin 3, and GDF-15 correlate with and predict systolic or diastolic dysfunction in patients with severe aortic stenosis scheduled for surgical aortic valve replacement?
Population
179 patients undergoing aortic valve replacement for severe aortic stenosis
Comparison
Plasma levels of NT-proBNP, sST2, Galectin 3, and GDF-15 evaluated against echocardiographic measurements
Design
Exploratory analysis of a prospective observational trial
Key result
Preoperative plasma levels of NT-proBNP significantly correlated with left ventricular global longitudinal strain (ρ=-0.40) and ejection fraction (ρ=-0.31) in patients with severe aortic stenosis.
Authors
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May inform preoperative LV assessment in severe AS; leaves open incremental value over echocardiography.
Observational (n=179)
No
Do preoperative plasma levels of NT-proBNP, sST2, Galectin 3, and GDF-15 correlate with and predict systolic or diastolic dysfunction in patients with severe aortic stenosis scheduled for surgical aortic valve replacement?
Effect estimate: ρ=-0.40
p-value: p=<0.001
In patients with severe aortic stenosis undergoing surgical valve replacement, NT-proBNP correlates with left ventricular systolic and diastolic dysfunction, whereas newer biomarkers like sST2, Galectin 3, and GDF-15 add little predictive value.
Desenfant et al. (2024) conducted an observational in Severe aortic stenosis (n=179). Preoperative plasma biomarkers (NT-proBNP, sST2, Galectin 3, GDF-15) was evaluated on Correlation between NT-proBNP and global longitudinal strain (GLS) (ρ=-0.40, p=<0.001). Preoperative plasma levels of NT-proBNP significantly correlated with left ventricular global longitudinal strain (ρ=-0.40) and ejection fraction (ρ=-0.31) in patients with severe aortic stenosis.