Key result
In hospitalized patients, mortality increased as serum sodium fell from 134 to 120 mEq/L but progressively decreased below 120 mEq/L, indicating underlying illness rather than hyponatremia drives mortality.
Authors
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May warrant caution attributing mortality to hyponatremia severity below 120 mEq/L; leaves open prospective trials on correction.
Observational (n=209,839)
No
Absolute Event Rate: 6.1% vs 2.3%
Chawla et al. (2011) conducted an observational in Hyponatremia (n=209,839). Hyponatremia (sNa ≤135 mEq/L) vs. Normonatremia (sNa >135 mEq/L) was evaluated on In-hospital mortality. In hospitalized patients, mortality increased as serum sodium fell from 134 to 120 mEq/L but progressively decreased below 120 mEq/L, indicating underlying illness rather than hyponatremia drives mortality.
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