Key result
Malignancy (HR 2.397; 95% CI 1.459-3.939), high phosphorus, and furosemide use were independently associated with increased mortality in patients hospitalized with moderate to severe hyponatremia.
Why the study?
Hyponatremia is associated with increased morbidity and mortality, but factors associated with mortality in patients hospitalized with moderate to severe hyponatremia required further investigation.
Population
337 patients hospitalized with moderate or severe hyponatremia
Design
Retrospective study
Authors
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May aid risk stratification in hyponatremia inpatients; leaves open causal links and need for prospective trials.
Observational (n=337)
Hazard Ratio: 2.397 (95% CI 1.459–3.939)
p-value: p=<0.001
Yavuz et al. (2025) conducted an observational in Moderate to severe hyponatremia (n=337). Malignancy vs. No malignancy was evaluated on Mortality (HR 2.397, 95% CI 1.459-3.939, p=<0.001). Malignancy (HR 2.397; 95% CI 1.459-3.939), high phosphorus, and furosemide use were independently associated with increased mortality in patients hospitalized with moderate to severe hyponatremia.
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