Key result
Severe hyponatremia linked to ~166% higher in-hospital mortality versus mild hyponatremia in patients ≥80.
Why the study?
This study aimed to explore the incidence, clinical features, etiology, and mortality of hyponatremia in older inpatients to provide preliminary epidemiological data.
Population
4364 older inpatients with hyponatremia
Comparison
Mild vs moderate vs severe hyponatremia
Design
Single-center observational study
Authors
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May warrant closer monitoring in hospitalized octogenarians; leaves open whether correction improves survival.
Observational (n=4,364)
No
Effect estimate: OR 2.66 (95% CI 2.06-3.43)
Absolute Event Rate: 20.7% vs 8.9%
p-value: p=<0.01
Hyponatremia is highly prevalent (24.7%) among hospitalized older adults, and its severity is strongly associated with increased in-hospital mortality and prolonged hospitalization.
Zhang et al. (2020) conducted an observational in Hyponatremia (n=4,364). Severe hyponatremia vs. Mild hyponatremia was evaluated on In-hospital mortality (OR 2.66, 95% CI 2.06-3.43, p=<0.01). Severe hyponatremia significantly increased in-hospital mortality compared to mild hyponatremia (OR 2.66) in hospitalized patients aged 80 years and older.
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