Key result
Successful reperfusion with intravenous streptokinase in acute myocardial infarction yielded a C-reactive protein response approximately 20% of that in patients without successful reperfusion.
Why the study?
Does intravenous streptokinase treatment alter the serum C-reactive protein response in patients with acute myocardial infarction?
Observational (n=23)
Does intravenous streptokinase treatment alter the serum C-reactive protein response in patients with acute myocardial infarction?
Successful thrombolysis with streptokinase markedly blunts the C-reactive protein response in acute myocardial infarction, suggesting CRP can be used to assess reperfusion success.
Answers are grounded in this paper and cite their sources.
Supports CRP evaluation as reperfusion marker after streptokinase; hypothesis-generating and requires prospective validation before clinical adoption.
Serum concentrations of C-reactive protein were studied in 23 patients with acute myocardial infarction. In 14 patients who did not receive thrombolytic treatment there was a linear relation between infarct size (determined by serial creatine kinase-MB determinations and thallium-201 isotope emission tomography) and the C-reactive protein response. The correlation coefficient between the concentration-time integrals of creatine kinase-MB and C-reactive protein was 0.96. The correlation coefficient between the creatine kinase-MB concentration-time integral and the peak serum value of C-reactive protein was 0.93. In the nine patients who received intravenous streptokinase treatment there was also a positive correlation between the concentration-time integrals of creatine kinase-MB and C-reactive protein. The relation, however, depended on the success of the treatment. In patients with successful reperfusion the C-reactive protein response was only approximately 20% of that in patients in whom reperfusion failed or who received no thrombolytic treatment and who were matched by infarct size. When thrombolysis was successful the correlation coefficient between the concentration-time integrals of creatine kinase-MB and C-reactive protein was 0.86. Daily measurement of serum C-reactive protein is useful in evaluating infarct size in patients with acute myocardial infarction who do not receive thrombolytic treatment. In patients treated with streptokinase C-reactive protein concentrations may be used to assess the success of thrombolysis.
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Pietilä et al. (1987) conducted an observational in acute myocardial infarction (n=23). Intravenous streptokinase vs. No thrombolytic treatment was evaluated on Correlation between concentration-time integrals of creatine kinase-MB and C-reactive protein. Successful reperfusion with intravenous streptokinase in acute myocardial infarction yielded a C-reactive protein response approximately 20% of that in patients without successful reperfusion.
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