Key result
Streptokinase administration in two patients with AMI resulted in early CK peaking at 10 and 12 hours, compared to delayed peaking at 26.4 hours in 384 untreated patients.
Why the study?
Does early CK peaking accurately identify successful coronary thrombolysis in patients with acute myocardial infarction?
Population
2 patients with transmural acute myocardial infarction treated with streptokinase, and a review cohort of…
Comparison
Streptokinase vs Untreated AMI (historical cohort of 384 patients)
Design
Case_series
Authors
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Early CK peaking may indicate successful thrombolysis; hypothesis-generating from two cases and requires prospective validation before clinical use.
Case Report (n=2)
Does early CK peaking accurately identify successful coronary thrombolysis in patients with acute myocardial infarction?
Early CK peaking appears to be an accurate noninvasive marker of successful coronary thrombolysis in patients with acute myocardial infarction.
J. A. Udall (1983) conducted a case report in Acute myocardial infarction (AMI) (n=2). Streptokinase vs. Untreated AMI was evaluated on Time to creatine kinase (CK) peaking. Streptokinase administration in two patients with AMI resulted in early CK peaking at 10 and 12 hours, compared to delayed peaking at 26.4 hours in 384 untreated patients.
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