Why the study?
What are the long-term light and electron microscopy findings in golden hamsters following intraperitoneal inoculation with coxsackie B3 virus?
Population
60 weaning Syrian golden hamsters
Design
Preclinical
Follow-up
Up to 14 months
Authors
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Offers hamster model of viral myocarditis progressing to cardiomegaly; leaves open human applicability.
What are the long-term light and electron microscopy findings in golden hamsters following intraperitoneal inoculation with coxsackie B3 virus?
Golden hamsters inoculated with coxsackie B3 virus develop acute myocarditis and occasionally chronic cardiomegaly, providing a unique model to study the relationship between viral myocarditis and idiopathic cardiomyopathy.
Hiroshi Morita (1981) studied this question.
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