Key result
Glycemic variability linked to diabetic vascular complications via oxidative stress-mediated endothelial dysfunction.
Why the study?
Endothelial dysfunction and platelet hyperactivation, two critical pathogenic factors in glycemic variability-induced diabetic complications, have not been fully elucidated.
Glycemic variability is a critical pathogenic factor in diabetic vascular complications, driven by endothelial dysfunction and platelet hyperactivation, highlighting the need for targeted glycemic stability.
Should not yet change practice to target variability; leaves open prospective trials on stability interventions.
The development and progression of the complications of chronic diabetes mellitus are attributed not only to increased blood glucose levels but also to glycemic variability. Therefore, a deeper understanding of the role of glycemic variability in the development of diabetic complications may provide more insight into targeted clinical treatment strategies in the future. Previously, the mechanisms implicated in glycemic variability-induced diabetic complications have been comprehensively discussed. However, endothelial dysfunction and platelet hyperactivation, which are two newly recognized critical pathogenic factors, have not been fully elucidated yet. In this review, we first evaluate the assessment of glycemic variability and then summarise the roles of endothelial dysfunction and platelet hyperactivation in glycemic variability-induced complications of diabetes, highlighting the molecular mechanisms involved and their interconnections.
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Huang et al. (2022) conducted a review in Diabetes mellitus with glycemic variability. Glycemic variability contributes to the development of diabetic vascular complications through mechanisms involving endothelial dysfunction and platelet hyperactivation mediated by oxidative stress.
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