Key result
MDD patients with suicidal ideation had reduced LF and HF power of pulse wave velocity compared to those without, with suicidal score correlating with LF (r=-0.54; p<0.05) and HF (r=0.54; p<0.01).
Why the study?
Is suicidal ideation in unmedicated MDD patients associated with altered pulse wave velocity variability?
Cross-Sectional (n=40)
No
Is suicidal ideation in unmedicated MDD patients associated with altered pulse wave velocity variability?
Reduced variability in pulse wave velocity in MDD patients with suicidal ideation suggests a potential link between severe depression symptoms and increased risk of arterial stiffness and future cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Suicidal ideation was associated with reduced PWV variability in MDD; hypothesis-generating for CV risk and requires prospective confirmation.
Recently arterial stiffness was found to be associated with depression. The aim of this study was to investigate the association between arterial pulse wave velocity (PWV) and Major Depressive Disorder (MDD) with or without suicidal ideation. Twenty unmedicated MDD patients with a history of suicidal ideations (Age: 32.37±9.53 years) and 20 unmedicated MDD patients without any history of suicidal ideations (Age: 36.84±8.66) were recruited for this study at a psychiatric clinic in the UAE. Depression severity was assessed with the Hamilton Depression Rating Scale and the Beck Depression Inventory. Pulse wave velocity (PWV) was estimated from the ratio of half of the height and Pulse Transit Time which is defined as the time delay between the R-wave of the ECG and the arrival of the pulse wave in the index finger respectively. MDD Patients with suicidal ideation were found to have reduced low frequency (LF) and high frequency (HF) power of PWV compared to MDD patients without suicidal ideations. Suicidal score was negatively correlated (r=−0.54;p<0.05) with LF power and positively (r=0.54; p<0.01) with HF power. No difference in the average PWV was found between the two groups of participants. Reduced variability in pulse wave velocity in MDD patients with suicidal ideation may lead to arterial stiffness and higher risk of future cardiovascular disease.
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Khandoker et al. (2015) conducted a cross-sectional in Major Depressive Disorder (MDD) (n=40). MDD with suicidal ideation vs. MDD without suicidal ideation was evaluated on Low frequency (LF) and high frequency (HF) power of pulse wave velocity (PWV) (r=-0.54 for LF, r=0.54 for HF, p=<0.05 for LF, <0.01 for HF). MDD patients with suicidal ideation had reduced LF and HF power of pulse wave velocity compared to those without, with suicidal score correlating with LF (r=-0.54; p<0.05) and HF (r=0.54; p<0.01).
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