Key result
Major depression with suicidal ideation linked to ~34% lower QT variability and increased QT/RR slope.
Why the study?
Does major depressive disorder with suicidal ideation alter ventricular repolarization parameters compared to MDD without suicidal ideation and healthy controls?
Case-Control (n=85)
No
Does major depressive disorder with suicidal ideation alter ventricular repolarization parameters compared to MDD without suicidal ideation and healthy controls?
Absolute Event Rate: 4.65% vs 7.08%
p-value: p=0.001
Depressed patients with suicidal ideation exhibit altered ventricular repolarization dynamics, specifically increased QT/RR slope and reduced QT variability, which may indicate increased vulnerability to arrhythmias.
QT alterations in suicidal MDD may signal arrhythmic vulnerability; leaves open predictive value and monitoring utility in prospective studies.
Major depressive disorder (MDD) is associated with a number of comorbidities including cardiovascular disease (CVD), with an increased risk of death after myocardial. The aim of this study was to investigate if parameters for ventricular repolarization variability and dynamics in ECG signals are different in MDD patients with/without suicidal ideation and healthy volunteers. Sixty-one ECG recordings (10 minutes) were acquired and analysed from control subjects (44 CONT), 20 MDD subjects with (MDDSI+) and 21 without suicidal ideation [SI] (MDDSI-) for a case-control analysis at a psychiatric clinic in the UAE. The Mini-International Neuropsychiatric Interview (MINI) made diagnoses of MDD and the subscale for was used to evaluate the patients' suicidal intensions [0 to 38]. The subscale for SI consists of 19 items, which was used to evaluate the patients' suicidal intensions [0 to 38]. Then heart ratecorrected QT interval (QTc), QT/RR slope, QT variability (QTV), Median T-wave amplitudes and T-wave variability were estimated. MDD patients with suicidal ideation displayed increased QT/RR slope and reduced QTV, which may reflect abnormal ventricular repolarization liability and lead to higher risk of cardiac arrhythmia and future cardiovascular diseases.
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Khandoker et al. (2016) conducted a case-control in Major Depressive Disorder with Suicidal Ideation (n=85). Major Depressive Disorder with Suicidal Ideation vs. Healthy controls and MDD without suicidal ideation was evaluated on QT variability (QTV) in ms (p=0.001). Major depressive disorder patients with suicidal ideation displayed significantly reduced QT variability and increased QT/RR slope compared to healthy controls.
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