Key result
The total PCV3-positive rate was 33.3% among 105 lung samples from sick pigs in Northeast China, with a high rate of co-infection with PCV2, PPV6, and PPV7.
Observational (n=105)
Yes
PCV3 is prevalent among sick pigs in Northeast China, frequently co-infects with other porcine viruses, and exhibits genetic variation including a novel strain with a truncated replicase protein.
PCV3 surveillance may be warranted in Northeast China swine; leaves open pathogenicity and co-infection impacts.
BACKGROUND: First identified in the United States in 2016, porcine circovirus type 3 (PCV3) is a newly emerging porcine circovirus exhibiting a wide range of clinical syndromes, which may be associated with the pathogenicity observed in pigs. RESULTS: The aim of this study was to identify and characterize the full genome sequence of PCV3 strains circulating in Northeast China. Herein, 105 lung samples isolated from sick pigs in Northeast China during 2018 were analyzed for PCV3. Using PCR, the total PCV3-positive rate was 33.3% (35/105), with rates of 17.8% (8/45), 66.7% (10/15), and 37.8% (17/45) in Heilongjiang, Jilin, and Liaoning province, respectively. Additionally, our findings showed that PCV3-positive samples had a high rate of co-infection with PCV2, PPV6, and PPV7. To study the evolution of the PCV3 in Northeast China, we sequenced the entire genome of 13 strains of PCV3. The results of phylogenetic analyses revealed that PCV3 could be divided into two clades, PCV3a and PCV3b. Interestingly, a G deletion at position 1072 was found in the 1999 nt genome of PCV3-CN2018LN-4 (MH277118). The G deletion terminated replicase protein translation and induced a truncated replicase protein. CONCLUSION: These results contribute to the understanding of PCV3 molecular epidemiology and evolution in Northeast China. A new strain of PCV3 with truncated replicase protein was identified.
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Ha et al. (2018) conducted an observational in Porcine circovirus 3 (PCV3) infection (n=105). The total PCV3-positive rate was 33.3% among 105 lung samples from sick pigs in Northeast China, with a high rate of co-infection with PCV2, PPV6, and PPV7.
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