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November 1, 1994AJP Regulatory Integrative and Comparative Physiology

Sympathetic activity and blood pressure are tightly coupled at 0.4 Hz in conscious rats

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Population

Rats (n=7 resting quietly in a cloth sock, n=6 roaming freely in their home cage, n=7 after anesthesia)

Comparison

Anesthesia with pentobarbital (30 mg/kg) vs Conscious state

Design

Preclinical

Follow-up

9.56 min

Authors

DBDavid R. BrownDuquesne University LBL. V. BrownUniversity of Kentucky APAbhijit PatwardhanUniversity of Kentucky

Discussion

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Implication

0.4 Hz SNA-BP coherence may index sympathetic drive in rat models; leaves open human translation and clinical utility.

Structured PICO

Population

Rats (n=7 resting quietly in a cloth sock, n=6 roaming freely in their home cage, n=7 after anesthesia)

Intervention

Anesthesia with pentobarbital (30 mg/kg)

Comparator

Conscious state (resting quietly or roaming freely)

Outcome

Power and coherence spectra below 3 Hz for sympathetic nerve activity (SNA), blood pressure (BP), and heart rate (HR)surrogate

Sympathetic nerve activity and blood pressure are tightly coupled at 0.4 Hz in rats, suggesting that blood pressure spectral power at this frequency may reliably reflect sympathetic activity.

Cite This Study

Brown et al. (1994) studied this question.

synapsesocial.com/papers/6a185b2836f65e9da61eb85e https://doi.org/10.1152/ajpregu.1994.267.5.r1378

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Sympathetic activity and blood pressure are tightly coupled at 0.4 Hz in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sympathetic activity and blood pressure are tightly coupled at 0.4 Hz in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider