What does this research mean for the field?

There is a direct relationship between the power spectra of blood pressure and sympathetic nerve activity, and acute changes in sympathetic tone specifically alter the low-frequency to high-frequency relationship in blood pressure variability. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1992AJP Heart and Circulatory Physiology

Spectrum analysis of sympathetic nerve activity and blood pressure in conscious rats

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Why the study?

Does pharmacological blockade alter the relationship between blood pressure and sympathetic nerve activity power spectra in conscious rats?

Population

9 Wistar-Kyoto rats (WKY) and 9 spontaneously hypertensive rats (SHR)

Comparison

Pharmacological blockade vs Baseline state before blockade

Design

Preclinical

Authors

PPPontus B. PerssonHumboldt-Universität zu Berlin HSHarald M. StaussVascular Medicine OCOk Yung ChungHeidelberg University

Discussion

Member takes

Implication

Rat BP-SNA spectral coherence may reflect sympathetic tone; leaves open translation to clinical sympathovagal assessment.

Structured PICO

Does pharmacological blockade alter the relationship between blood pressure and sympathetic nerve activity power spectra in conscious rats?

Population

9 Wistar-Kyoto rats (WKY) and 9 spontaneously hypertensive rats (SHR)

Intervention

Pharmacological blockade (alpha 1-adrenoceptor blockade with prazosin, parasympathetic blockade with methylscopolamine)

Comparator

Baseline state before blockade

Outcome

Relationship between blood pressure (BP) and sympathetic nerve activity (SNA) power spectra (coherence, phase lag, proportional LF and HF power)surrogate

This preclinical study demonstrates a direct relationship between blood pressure and sympathetic nerve activity power spectra, with acute changes in sympathetic tone altering the LF-HF relationship.

Cite This Study

Persson et al. (1992) studied this question.

synapsesocial.com/papers/6a185b2836f65e9da61eb85f https://doi.org/10.1152/ajpheart.1992.263.5.h1348

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Spectrum analysis of sympathetic nerve activity and blood pressure in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Spectrum analysis of sympathetic nerve activity and blood pressure in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider