June 1, 1995Hypertension

Sympathectomy and Cardiovascular Spectral Components in Conscious Normotensive Rats

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Population

Spontaneously behaving normotensive Wistar-Kyoto rats (n=34)

Comparison

Chemical sympathectomy with 6-hydroxydopamine… vs Vehicle

Design

Preclinical

Authors

ADAnna DaffonchioIstituto di Fisiologia Clinica CFCristina FranzelliIstituto Ortopedico Gaetano Pini ARAlberto RadaelliAzienda Ospedaliera San Gerardo

Discussion

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Implication

Questions BP spectral powers as sympathetic markers in conscious rats; leaves open their validity for autonomic research.

Structured PICO

Population

Spontaneously behaving normotensive Wistar-Kyoto rats (n=34)

Intervention

Chemical sympathectomy with 6-hydroxydopamine (150 mg/kg twice in 1 week), with additional monitoring sessions under alpha-adrenergic receptor blockade (phenoxybenzamine), beta-receptor blockade (propranolol), or cholinergic receptor blockade (atropine)

Comparator

Vehicle

Outcome

Spectral powers of blood pressure and pulse interval in low-frequency (0.025 to 0.1 Hz), mid-frequency (0.1 to 0.6 Hz), and high-frequency (0.8 to 3.0 Hz) bandssurrogate

Spectral powers of blood pressure and pulse interval in the mid- and low-frequency ranges cannot be regarded as specific markers of sympathetic activity in conscious rats.

Cite This Study

Daffonchio et al. (1995) studied this question.

synapsesocial.com/papers/6a754c096a5eb4b8f5095f83 https://doi.org/10.1161/01.hyp.25.6.1287

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Sympathectomy and Cardiovascular Spectral Components in Conscious Normotensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sympathectomy and Cardiovascular Spectral Components in Conscious Normotensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider