What question did this study set out to answer?

To determine the regional hemodynamic mechanisms responsible for increased arterial pressure variability after chronic chemical sympathectomy.

July 1, 1994AJP Heart and Circulatory Physiology

Hemodynamic analysis of arterial pressure lability in sympathectomized rat

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Why the study?

Does chronic sympathectomy with guanethidine affect mean arterial pressure lability in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats (n=26)

Comparison

Guanethidine treatment from 1 to 13 weeks of age vs Saline treatment from 1 to 13 weeks of age

Design

Preclinical

Follow-up

12 weeks (from 1 to 13 weeks of age)

Authors

ZZZ. Q. ZhangBinzhou Medical University CJClaude JulienUniversité Claude Bernard Lyon 1 MGMarie‐Paule GustinUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Supports sympathetic buffering of MAP variability in rats; leaves open translation to human autonomic regulation.

Key Points

To determine the regional hemodynamic mechanisms responsible for increased arterial pressure variability after chronic chemical sympathectomy.
Treated male Sprague-Dawley rats with either saline (n = 14) or guanethidine (n = 12) from 1 to 13 weeks of age to produce chronic sympathectomy.
Implanted pulsed Doppler flow probes to record beat-to-beat mean arterial pressure (MAP) and regional blood flows in the subdiaphragmatic aorta, superior mesenteric artery, and distal aorta of conscious rats.
Evaluated hemodynamics during spontaneous pressure swings before and after acute beta-adrenoceptor blockade.
Chronic sympathectomy did not alter baseline MAP levels but nearly doubled spontaneous MAP variability compared to saline-treated controls.
Pressure lability was driven by large MAP drops accompanied by delayed vasodilation in the aortic and mesenteric beds, while hindquarter blood flow remained steady or increased.
Acute beta-adrenoceptor blockade had no effect on the observed hemodynamic pattern.

Structured PICO

Does chronic sympathectomy with guanethidine affect mean arterial pressure lability in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats (n=26)

Intervention

Guanethidine treatment from 1 to 13 weeks of age (chronic sympathectomy)

Comparator

Saline treatment from 1 to 13 weeks of age

Outcome

Mean arterial pressure (MAP) and its spontaneous variability, and indexes of regional blood flowssurrogate

Chronic sympathectomy sensitizes the cardiovascular system to decreases in arterial pressure by unmasking local autoregulatory responses, demonstrating that sympathetic control limits MAP variability.

Cite This Study

Zhang et al. (1994) studied this question.

synapsesocial.com/papers/6a912cf75a27f97d0d65e209 https://doi.org/10.1152/ajpheart.1994.267.1.h48

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Hemodynamic analysis of arterial pressure lability in sympathectomized rat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hemodynamic analysis of arterial pressure lability in sympathectomized rat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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