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October 1, 1991AJP Regulatory Integrative and Comparative Physiology

Blood pressure maintenance in hypertensive sympathectomized rats. II. Renin-angiotensin system and vasopressin

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Population

Genetically hypertensive rats of the Lyon strain and normotensive control rats, either intact or…

Comparison

Sequential blockade of the renin-angiotensin… vs Normotensive control (LN) rats and intact rats

Design

Preclinical

Authors

MLMing LoUniversité Claude Bernard Lyon 1CBC. BarrèsUniversité Côte d'AzurIMIsac Almeida de MedeirosUniversidade Federal da Paraíba

Discussion

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Implication

Suggests intrinsic vascular resistance sustains hypertension in sympathectomized genetic models; leaves open relevance to human disease mechanisms or therapy.

Structured PICO

P
Population
Genetically hypertensive (LH) rats of the Lyon strain and normotensive control (LN) rats, either intact or sympathectomized with guanethidine
I
Intervention
Sequential blockade of the renin-angiotensin system, vasopressin receptors, the autonomic nervous system, and maximal vasodilation with hydralazine
C
Comparator
Normotensive control (LN) rats and intact rats
O
Outcome
Blood pressure (BP)surrogate

In sympathectomized genetically hypertensive rats, hypertension is maintained by increased intrinsic vascular resistance rather than hyperactivity of pressor systems.

Cite This Study

Lo et al. (1991) studied this question.

synapsesocial.com/papers/6a8859d533299ecf904fdd80https://doi.org/10.1152/ajpregu.1991.261.4.r1052

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of sympathectomy on blood pressure and its variability in conscious rats1990 · 47 citations
  2. 2Pivotal role of the renin-angiotensin system in Lyon hypertensive rats1997 · 22 citations
  3. 3Renin Secretion in Lyon Hypertensive Rats1997 · 6 citations
  4. 4Renin-angiotensin system in two genetically normotensive strains of lyon rats2000 · 2 citations
  5. 5High blood pressure maintenance in transgenic mRen-2 vs. Lyon genetically hypertensive rats1993 · 10 citations