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January 1, 1997Clinical and Experimental Hypertension

Renin Secretion in Lyon Hypertensive Rats

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Population

Genetically hypertensive rats of Lyon strain (LH)

Design

Preclinical

Authors

CJClaude JulienUniversité Claude Bernard Lyon 1SBS. BertolinoUniversity of FoggiaIMIsac Almeida de MedeirosUniversidade Federal da Paraíba

Discussion

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Implication

LH rat renin paradox suggests RAS sensitivity despite low secretion; leaves open mechanisms and human translation in low-renin hypertension.

Structured PICO

P
Population
Genetically hypertensive rats of Lyon strain (LH)
I
Intervention
Chronic sodium deprivation, hydralazine, or perindopril treatment
O
Outcome
Renin secretory profile (basal plasma renin concentration and renin responses to reductions of renal perfusion pressure and beta-adrenoceptor stimulation)surrogate

Lyon hypertensive rats present a 'renin paradox' where hypertension is sensitive to renin-angiotensin system blockade despite a low and blunted renin secretory profile.

Cite This Study

Julien et al. (1997) studied this question.

synapsesocial.com/papers/6a885a87ceefe68dba4fcdf1https://doi.org/10.3109/10641969709083180

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pressure control of renal renin release in Lyon hypertensive rats1994 · 4 citations
  2. 2Enhanced renal angiotensin II subtype 1 receptor responses in the spontaneously hypertensive rat.1993 · 73 citations
  3. 3Renal Nerves, Renin, and Angiotensinogen Gene Expression in Spontaneously Hypertensive Rats1995 · 33 citations
  4. 4Pressure-dependent renin release and arterial pressure maintenance in conscious rats1994 · 14 citations
  5. 5Direct Demonstration of Macula Densa-Mediated Renin Secretion1987 · 216 citations