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July 1, 1993AJP Regulatory Integrative and Comparative Physiology

High blood pressure maintenance in transgenic mRen-2 vs. Lyon genetically hypertensive rats

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Population

Adult transgenic mRen-2 (TG) rats and age-matched Lyon genetically hypertensive rats (LH)

Comparison

Transgenic mRen-2 (TG) model vs Lyon genetically hypertensive (LH) model

Design

Preclinical

Authors

MLMing LoUniversité Claude Bernard Lyon 1IMIsac Almeida de MedeirosUniversidade Federal da ParaíbaJMJohn J. MullinsPreventive Cardiology

Discussion

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Implication

TG rat sodium handling and RAS responses extend preclinical low-renin hypertension models; human translation remains open.

Structured PICO

P
Population
Adult transgenic mRen-2 (TG) rats and age-matched Lyon genetically hypertensive rats (LH)
I
Intervention
Transgenic mRen-2 (TG) model
C
Comparator
Lyon genetically hypertensive (LH) model
O
Outcome
Renal handling of sodium, sympathetic activity, and renin-angiotensin system (RAS) activitysurrogate

Adult TG rats exhibit a tendency toward sodium and water retention, explaining the involvement of the RAS in maintaining high BP despite low renin levels.

Cite This Study

Lo et al. (1993) studied this question.

synapsesocial.com/papers/6a908efa55a9abd3b0841be6https://doi.org/10.1152/ajpregu.1993.265.1.r180

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin-angiotensin system in two genetically normotensive strains of lyon rats2000 · 2 citations
  2. 2Pivotal role of the renin-angiotensin system in Lyon hypertensive rats1997 · 22 citations
  3. 3Renin Secretion in Lyon Hypertensive Rats1997 · 6 citations
  4. 4Analysis of phenotypic consequences of renin gene polymorphism in Lyon rats1997 · 9 citations
  5. 5In the Lyon hypertensive rat, renal function alterations are angiotensin II dependent1996 · 22 citations