Why the study?
Does RAS blockade with perindopril prevent renal alterations and hypertension in Lyon hypertensive rats?
Population
Lyon hypertensive (LH) rats and normotensive (LN) controls
Comparison
Perindopril and acute infusion of angiotensin II vs Untreated LH rats and LN controls
Design
Preclinical
Follow-up
12 weeks (from 3 to 15 weeks of age)
Authors
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Reinforces RAS dependence in Lyon hypertensive rat model; leaves open translation to human hypertension management.
Does RAS blockade with perindopril prevent renal alterations and hypertension in Lyon hypertensive rats?
In the Lyon hypertensive rat model, blood pressure and renal function alterations are highly dependent on an active renin-angiotensin system.
Liu et al. (1996) studied this question.
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