Why the study?
Does early and prolonged RAS blockade with perindopril or losartan improve blood pressure and renal lesions in male Lyon hypertensive rats after treatment withdrawal?
Population
Male Lyon hypertensive (LH) rats
Comparison
Oral perindopril or losartan from 3 to 12 weeks… vs Never-treated LH rats
Design
Preclinical
Follow-up
10 weeks after cessation of treatment
Authors
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Animal data show lasting nephroprotection after RAS blockade withdrawal in rats; extends preclinical evidence but leaves open human translation.
Does early and prolonged RAS blockade with perindopril or losartan improve blood pressure and renal lesions in male Lyon hypertensive rats after treatment withdrawal?
Early RAS blockade in Lyon hypertensive rats provides durable nephroprotection that persists after treatment withdrawal, independent of long-term blood pressure lowering.
Bertram et al. (2002) studied this question.
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