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November 1, 1997AJP Regulatory Integrative and Comparative Physiology

Pivotal role of the renin-angiotensin system in Lyon hypertensive rats

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Population

Lyon genetically hypertensive (LH) and normotensive (LN) rats

Comparison

ACE inhibition followed by 4-week infusion of… vs Untreated LH rats and LN rats

Design

Preclinical

Follow-up

12 weeks (from 3 to 15 weeks of age)

Authors

PLPierre LantelmeUniversité Claude Bernard Lyon 1MLMing LoUniversité Claude Bernard Lyon 1LLLaurent Luttenauer

Discussion

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Implication

Preclinical data preclude practice change; confirms ANG II dependence over NE in this low-renin genetic model.

Structured PICO

P
Population
Lyon genetically hypertensive (LH) and normotensive (LN) rats
I
Intervention
ACE inhibition (perindopril, 3 mg/kg/24h orally from 3 to 15 weeks of age) followed by 4-week infusion of ANG II (200 ng/kg/min) or NE (1,000 ng/kg/min)
C
Comparator
Untreated LH rats and LN rats
O
Outcome
Blood pressure, regional hemodynamics, cardiac hypertrophy, and kidney renin/prorenin contentssurrogate

Hypertension in Lyon genetically hypertensive rats is fully dependent on an active renin-angiotensin system despite low basal renin secretion.

Cite This Study

Lantelme et al. (1997) studied this question.

synapsesocial.com/papers/6a76517270b84e52bb88016fhttps://doi.org/10.1152/ajpregu.1997.273.5.r1793

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin secretion in conscious Lyon hypertensive rats1996 · 12 citations
  2. 2Blood pressure maintenance in hypertensive sympathectomized rats. II. Renin-angiotensin system and vasopressin1991 · 18 citations
  3. 3Lack of Increased Renin-Angiotensin Activity in Rats with Spontaneous Hypertension1970 · 58 citations
  4. 4Contribution of the sympathetic nervous system to vascular resistance in conscious young and adult spontaneously hypertensive rats.1980 · 78 citations
  5. 5Seven renin alleles in rats and their effects on blood pressure1994 · 51 citations