Why the study?
Does fetal and neonatal renin-angiotensin system blockade with captopril prevent long-term hypertension in Lyon genetically hypertensive rats?
Population
Lyon genetically hypertensive (LH) rats
Comparison
Captopril administered from conception to age 3… vs Untreated LH rats
Design
Preclinical
Follow-up
14 weeks of age
Authors
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Early captopril fails to lower long-term BP or LV mass in Lyon rats; leaves open strain-specific effects of neonatal RAS blockade.
Does fetal and neonatal renin-angiotensin system blockade with captopril prevent long-term hypertension in Lyon genetically hypertensive rats?
Unlike in spontaneously hypertensive rats, early transient ACE inhibition with captopril does not produce long-term blood pressure reduction in Lyon genetically hypertensive rats.
Florin et al. (1999) studied this question.