Why the study?
Does the renin-angiotensin system maintain arterial blood pressure in hypophysectomized rats?
Population
Hypophysectomized rats
Comparison
Saralasin, captopril, or growth hormone vs Baseline state or normal rats
Design
Preclinical
Authors
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RAS blockade lowers BP further in hypophysectomized rats; leaves open relevance to human physiology or therapy.
Does the renin-angiotensin system maintain arterial blood pressure in hypophysectomized rats?
The renin-angiotensin system plays a crucial role in maintaining arterial blood pressure in hypophysectomized rats, despite decreased secretory responsiveness.
Simon et al. (1984) studied this question.
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