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April 1, 1970Endocrinology

Influence of the Pituitary Gland on Sodium Conservation, Plasma Renin and Renin Substrate Concentrations in the Rat

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Population

Normal and hypophysectomized rats

Comparison

Changes in dietary sodium intake vs Rats drinking 0.18% saline

Design

Preclinical

Follow-up

13 days

Authors

FGF. J. GoodwinSt Bartholomew's HospitalJKJ. Dianne KirshmanColumbia UniversityJSJean E. SealeyPreventive Cardiology

Discussion

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Implication

Hypothesis-generating for pituitary-independent renin responsiveness in rats; leaves open translation to human physiology or practice.

Structured PICO

P
Population
Normal and hypophysectomized rats
I
Intervention
Changes in dietary sodium intake (sodium deprivation for 13 days, or administration of 0.45% and 0.9% sodium chloride in drinking water)
C
Comparator
Rats drinking 0.18% saline
O
Outcome
Plasma renin concentration and plasma renin substrate concentrationsurrogate

The study demonstrates that the renin-angiotensin system's responsiveness to sodium deprivation is maintained in hypophysectomized rats, although hypophysectomy reduces plasma renin substrate concentration.

Cite This Study

Goodwin et al. (1970) studied this question.

synapsesocial.com/papers/6a81682b61368bff2d6912fehttps://doi.org/10.1210/endo-86-4-824
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin-angiotensin system in hypophysectomized rats. I. Control of blood pressure1984 · 8 citations
  2. 2Renin-Angiotensin-Aldosterone System in Hyper- and Hypothyroid Rats During Sodium Depletion1982 · 5 citations
  3. 3Role of the Renin-Angiotensin System in the Regulation of Aldosterone Secretion in the Rat1965 · 48 citations
  4. 4Sodium-Mediated Modulation of Aldosterone Secretion: Impact of Converting Enzyme Inhibition on Rat Glomerulosa Cell Response to Angiotensin-II*1989 · 7 citations
  5. 5The Renin-Angiotensin System and Aldosterone Secretion during Sodium Depletion in the Rat1974 · 63 citations