Population
Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats at 6 weeks of age (normotensive)
Comparison
Nephrectomy and/or sodium-deficient diet for 2… vs Dahl salt-resistant (R) rats
Design
Preclinical
Follow-up
2 weeks
Authors
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Should not yet change hypertension practice; leaves open adrenal renin suppression in salt-sensitive models.
Dahl salt-sensitive rats exhibit suppressed adrenal zona glomerulosa renin and aldosterone levels with a blunted response to nephrectomy, independent of volume expansion.
Baba et al. (1986) studied this question.