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January 1, 1982Endocrine Research Communications

Renin-Angiotensin-Aldosterone System in Hyper- and Hypothyroid Rats During Sodium Depletion

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Why the study?

Does sodium depletion affect the renin-angiotensin-aldosterone system in hyper- and hypothyroid rats?

Population

Hyper- and hypothyroid rats, and euthyroid rats

Comparison

Sodium depletion (sodium deficient diet) vs Normal sodium diet

Design

Preclinical

Authors

MMMercedes MontielLight Prescriptions Innovators (Spain)EJElisabeth JiménezConsejo Superior de Investigaciones CientíficasJNJosé Ángel NarváezInstituto de Investigación Biomédica de Málaga

Discussion

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Implication

Sodium depletion dominates RAAS activation over thyroid status in rats; leaves open translation to human thyroid disorders.

Structured PICO

Does sodium depletion affect the renin-angiotensin-aldosterone system in hyper- and hypothyroid rats?

P
Population
Hyper- and hypothyroid rats, and euthyroid rats
I
Intervention
Sodium depletion (sodium deficient diet)
C
Comparator
Normal sodium diet
O
Outcome
Plasma renin concentration (PRC) and serum aldosterone concentration (AC)surrogate

Sodium depletion is a stronger stimulus for the renin-angiotensin-aldosterone system than thyroid hormone alterations in a rat model.

Cite This Study

Montiel et al. (1982) studied this question.

synapsesocial.com/papers/6a89a944b4e829b19bd45891https://doi.org/10.3109/07435808209045768
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of the Pituitary Gland on Sodium Conservation, Plasma Renin and Renin Substrate Concentrations in the Rat1970 · 25 citations
  2. 2The Renin-Angiotensin System in Thyroidectomized Rats*1981 · 46 citations
  3. 3Role of the renin-angiotensin system in the adaptation of aldosterone biosynthesis to sodium restriction in the rat1980 · 15 citations
  4. 4Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects<sup>1</sup>1969 · 2,239 citations
  5. 5A rapid simple method for the assay of renin in rabbit plasma1968 · 52 citations