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March 1, 1992Acta Physiologica Scandinavica

Trophic effects of hypophyseal hormones on resistance vessels and the heart in normotensive and renal hypertensive rats

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Why the study?

Do pituitary hormones influence the relationship between blood pressure and cardiovascular structure in normotensive and renal hypertensive rats?

Population

Male Sprague-Dawley rats, aged 5 weeks

Comparison

Hypophysectomy with or without replacement… vs Intact control rats

Design

Preclinical

Follow-up

5 weeks

Authors

BFBjörn FolkowSwedish Defence UniversityOIOlle IsakssonUniversity of GothenburgGKGunnar KarlströmUniversidade Federal do Rio de Janeiro

Discussion

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Implication

Pituitary hormones may support vascular adaptation to hypertension in rats; leaves open relevance to human cardiovascular remodeling.

Structured PICO

Do pituitary hormones influence the relationship between blood pressure and cardiovascular structure in normotensive and renal hypertensive rats?

P
Population
Male Sprague-Dawley rats, aged 5 weeks
I
Intervention
Hypophysectomy with or without replacement therapy (growth hormone and thyroxine), followed by unilateral renal artery clipping (to induce hypertension) or no clipping
C
Comparator
Intact control rats (normotensive and hypertensive)
O
Outcome
Relationship between systolic blood pressure and cardiovascular structure (left ventricular weight, resistance at maximal dilatation, maximal pressor response)surrogate

Growth hormone and thyroxine are essential for the maturation of the cardiovascular system and its structural adaptation to hypertension.

Cite This Study

Folkow et al. (1992) studied this question.

synapsesocial.com/papers/6a7323cc9114ba2b47c231bfhttps://doi.org/10.1111/j.1748-1716.1992.tb09298.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pathogenesis of Arterial Hypertension after the Constriction of the Renal Artery Leaving the opposite Kidney Intact Both in the Anaesthetized and in the Conscious Dog1972 · 73 citations
  2. 2Rate and Extent of Adaptive Cardiovascular Changes in Rats during Experimental Renal Hypertension1974 · 91 citations
  3. 3Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism.1991 · 396 citations
  4. 4Functional, morphological and metabolic characteristics of isolated hearts from normotensive and spontaneously hypertensive rats before, during and after renal hypertension1986 · 9 citations
  5. 5Left ventricular hypertrophy improves cardiac performance in spontaneously hypertensive rats1982 · 20 citations