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December 1, 1978Cardiovascular Research

Chronic antihypertensive drug treatment in young spontaneously hypertensive rats: effects on arterial blood pressure, cardiovascular reactivity and vascular design

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Why the study?

Does early prolonged antihypertensive treatment improve arterial blood pressure, cardiovascular reactivity, and vascular design in spontaneously hypertensive rats?

Population

Male spontaneously hypertensive rats

Comparison

Propranolol, metoprolol, hydralazine, or… vs Untreated matched spontaneously hypertensive rats

Design

Preclinical

Follow-up

approx 9 months (between 3 weeks and 10 months of age)

Authors

LWLeonard WeissUniversity of PittsburghYLYen LundgrenSahlgrenska University Hospital

Discussion

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Implication

Early BP control in SHR fails to fully prevent vascular remodeling; leaves open genetic roles in resistance vessel design beyond hemodynamics.

Structured PICO

Does early prolonged antihypertensive treatment improve arterial blood pressure, cardiovascular reactivity, and vascular design in spontaneously hypertensive rats?

P
Population
Male spontaneously hypertensive rats
I
Intervention
Propranolol, metoprolol, hydralazine, or guanethidine and hydralazine in combination, administered between 3 weeks and 10 months of age
C
Comparator
Untreated matched spontaneously hypertensive rats
O
Outcome
Changes in heart rate and mean arterial pressure in response to stressful stimuli, and structural characteristics of resistance vessels (resistance at maximal dilatation, gradient of the curve, and maximal pressor response)surrogate

Early pharmacological normalization of mean arterial pressure in spontaneously hypertensive rats does not fully prevent structural cardiovascular changes, suggesting a genetic predisposition involving cardiovascular effectors.

Cite This Study

Weiss et al. (1978) studied this question.

synapsesocial.com/papers/6a7f3dc4b1a7ff7f700dff56https://doi.org/10.1093/cvr/12.12.744

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1INFLUENCE OF ANTI‐HYPERTENSIVE DRUG TREATMENT ON VASCULAR REACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS1975 · 18 citations
  2. 2Effects of Prolonged Treatment with Adrenergic β‐receptor Antagonists on Blood Pressure, Cardiovascular Design and Reactivity in Spontaneously Hypertensive Rats (SHR)1974 · 104 citations
  3. 3Alteration of the Course of Hypertension in the Spontaneously Hypertensive Rat1972 · 96 citations
  4. 4Time Course and Extent of Structural Vascular Adaptation to Regional Hypotension in Adult Spontaneously Hypertensive Rats (SHR)1974 · 23 citations
  5. 5Blood Pressure and Vascular Design in Renal Hypertension in Rats after Prolonged Propranolol Treatment1974 · 25 citations