Effects of short‐ and long‐term sympathectomy on vasoconstrictor responses of the rat mesenteric arterial bed
Key result
Short- and long-term sympathectomy in rats markedly reduced nerve-mediated vasoconstrictor responses, causing non-uniform changes in smooth muscle sensitivity to vasoconstrictors.
Population
Constantly perfused mesenteric arterial beds isolated from adult rats
Comparison
Short-term sympathectomy and long-term… vs Mesenteric arterial preparations from untreated…
Design
Preclinical
Authors
Discussion
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Implication
Threshold for vasoconstrictor changes requires near-complete denervation in rat mesentery; leaves open human vascular applicability.
Structured PICO
P
Population
Adult rats evaluated for the effects of short- and long-term sympathectomy on vasoconstrictor function of isolated mesenteric arterial beds.
I
Intervention
Short-term sympathectomy (6-hydroxydopamine [6-OHDA] treatment, assessed at 3 and 8 days) and long-term sympathectomy (guanethidine treatment at youth)
C
Comparator
Mesenteric arterial preparations from untreated control rats
O
Outcome
Vasoconstrictor responses to electrical field stimulation (EFS) and various pharmacological agentssurrogate
Changes in smooth muscle responses to vasoconstrictors after sympathetic denervation in the rat mesenteric arterial bed generally only occur with near-complete loss of nerve-mediated responses.
Cite This Study
Ralevic et al. (1996) studied this question. Sympathectomy (6-OHDA or guanethidine) vs. Untreated controls was evaluated on Vasoconstrictor responses to electrical field stimulation. Short- and long-term sympathectomy in rats markedly reduced nerve-mediated vasoconstrictor responses, causing non-uniform changes in smooth muscle sensitivity to vasoconstrictors.