February 1, 2002Journal of Applied Physiology
Effects of chronic sympathectomy on locally mediated cutaneous vasodilation in humans
Key result
Chronic T(2) sympathectomy preserved cutaneous endothelial function, with maximal vasodilation showing no difference between groups, though the nadir was absent in sympathectomized arms (P>0.10).
Why the study?
Does chronic sympathectomy diminish endothelium-dependent vasodilation in human skin?
Population
Individuals who had previously undergone surgical T sympathectomy and a group of healthy controls
Comparison
30 min of local warming to 42.5 degrees C on the… vs Healthy controls with intact sympathetic…
Design
Case-control
Authors
Discussion
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Implication
Cutaneous endothelial function remains intact after chronic T2 sympathectomy; hypothesis-generating for sympathetic modulation of nitric oxide kinetics.
Study Design
Type
Observational (n=17)
Structured PICO
Does chronic sympathectomy diminish endothelium-dependent vasodilation in human skin?
P
Population
Individuals who had previously undergone surgical T(2) sympathectomy (n=9) and a group of healthy controls (n=8)
I
Intervention
30 min of local warming to 42.5 degrees C on the ventral forearm (no sympathetic innervation) and the lower legs (sympathetic nerves intact)
C
Comparator
Healthy controls with intact sympathetic innervation
O
Outcome
Cutaneous vascular response measured by laser-Doppler during 30 min of local warmingsurrogate
Endothelial function in human skin is largely preserved after chronic sympathectomy, though the nitric oxide-dependent vasodilation may be accelerated.
Cite This Study
Charkoudian et al. (2002) conducted an observational in Chronic sympathectomy (n=17). Surgical T(2) sympathectomy vs. Healthy controls and innervated lower legs was evaluated on Cutaneous vascular response (endothelium-dependent vasodilation) to local warming. Chronic T(2) sympathectomy preserved cutaneous endothelial function, with maximal vasodilation showing no difference between groups, though the nadir was absent in sympathectomized arms (P>0.10).