Key result
Complete lumbar sympathectomy abolished the vasodilatory response to dorsal column stimulation in skin and muscle, indicating the sympathetic system's major role in DCS-induced vasodilation.
Why the study?
Does dorsal column stimulation induce peripheral vasodilation via the sympathetic nervous system in normal rats?
Population
Normal rats divided into three groups: lumbar sympathectomy, sham-operated, and no pretreatment control.
Comparison
Electric stimulation of the dorsal spinal cord… vs Sham-operated rats and rats without pretreatment.
Design
Preclinical
Authors
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Hypothesis-generating for sympathetic mediation of DCS vasodilation in rats; leaves open translation to clinical spinal cord stimulation.
Does dorsal column stimulation induce peripheral vasodilation via the sympathetic nervous system in normal rats?
The vasodilatory effect of dorsal column stimulation on peripheral microcirculation is largely dependent on the sympathetic nervous system, likely via inhibition of sympathetic vasoconstrictor activity.
Linderoth et al. (1991) studied normal rats. Lumbar sympathectomy followed by dorsal spinal cord stimulation vs. Sham-operated and unoperated controls was evaluated on Peripheral microcirculation changes (vasodilation) in hind limb skin and muscle. Complete lumbar sympathectomy abolished the vasodilatory response to dorsal column stimulation in skin and muscle, indicating the sympathetic system's major role in DCS-induced vasodilation.
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