Population
Normal rats divided into three groups: lumbar sympathectomy, sham-operated, and no pretreatment control.
Comparison
Electric stimulation of the dorsal spinal cord… vs Sham-operated rats and rats without pretreatment.
Design
Preclinical
Authors
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Sympathetic mediation of DCS vasodilation at clinical parameters in animals leaves open translation to human spinal cord stimulation.
The sympathetic system plays a major role in DCS-induced peripheral vasodilation, likely through stimulation-induced activation of spinal inhibitory mechanisms depressing sympathetic vasoconstrictor activity.
Linderoth et al. (1991) studied this question.
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