Key result
Sympathectomy significantly increased blood pressure variability in both Wistar-Kyoto (+61%) and spontaneously hypertensive rats (+86%) compared to vehicle-treated controls (both P<0.01).
Why the study?
Does sympathectomy and/or cholinergic blockade alter overall blood pressure variability in unanesthetized rats?
Population
Chronically instrumented, freely behaving Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Sympathectomy by 6-hydroxydopamine twice in 1 wk… vs Vehicle-treated controls
Design
Preclinical
Follow-up
90 minutes
Authors
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Sympathectomy may elevate BP variability in rats; leaves open whether sympathetic buffering of variability translates to human hypertension or device therapies.
Does sympathectomy and/or cholinergic blockade alter overall blood pressure variability in unanesthetized rats?
p-value: p=< 0.01
In unanesthetized rats, sympathetic influences oppose blood pressure variations, and when lost, vagally mediated heart rate variations oppose the rise in blood pressure variability.
Ferrari et al. (1996) studied Spontaneously hypertensive and normotensive rats. Sympathectomy by 6-hydroxydopamine and/or cholinergic blockade by atropine vs. Vehicle-treated controls was evaluated on Overall blood pressure variability (p=< 0.01). Sympathectomy significantly increased blood pressure variability in both Wistar-Kyoto (+61%) and spontaneously hypertensive rats (+86%) compared to vehicle-treated controls (both P<0.01).
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