Why the study?
Does chemical sympathectomy by 6-hydroxydopamine improve baroreceptor reflex sensitivity in conscious WKY and SHR rats?
Population
Conscious Wistar-Kyoto rats and spontaneously hypertensive rats, as well as anesthetized, vagotomized SHR…
Comparison
Chemical sympathectomy by 6-hydroxydopamine vs Vehicle
Design
Preclinical
Authors
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Hypothesis-generating for sympathetic modulation of baroreflex in hypertension models; leaves open translation to human therapies.
Does chemical sympathectomy by 6-hydroxydopamine improve baroreceptor reflex sensitivity in conscious WKY and SHR rats?
Chemical sympathectomy potentiates the baroreceptor-heart rate reflex in both normotensive and hypertensive rats, suggesting sympathetic activity normally interferes with this reflex.
Ferrari et al. (1991) studied this question.
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